Dark Matter eLiquid

Enjoy the wonderful flavor of our latest VapeSafe eLiquid - Dark Matter.

Dark Matter tastes like German chocolate cake. For those of you who have not had the fortunate to try a piece German chocolate cake recently, this is a great way to experience the flavor without getting any of the calories. German chocolate cake is a layered cake filled and topped with a coconut-pecan frosting. Traditionally sweet baking chocolate is used for the chocolate flavor in the actual cake. The robust filling and topping is a caramel made with egg yolks and evaporated milk. Once the caramel is cooked, coconut and pecans are stirred into the mixture. Finally, rich chocolate frosting is spread around the sides of the cake to hold in the filling.

Dark Matter eLiquid by VapeSafe captures the essence of German chocolate cake. Dark Matter eLiquid delivers plumes of vapor and rich chocolatey flavor that you'll want to enjoy again and again. Try Dark Matter today!

Technology Information:

Pharmacokinetics of M6G following intravenous and oral administration [An article from: Acute Pain

Description

This digital document is a journal article from Acute Pain, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Abstract:
Background: The active metabolite of morphine, morphine-6-glucuronide (M6G), shows an analgesic effect that is equivalent to morphine. The bioavailability is low (11-13%) when given orally due to poor absorption from the GI-tract and further the absorption seems to be biphasic. The aims of this study were to determine the pharmacokinetics after intravenous administration (i.v.) of M6G in humans, to elucidate the absorption profile of M6G after oral administration, and to evaluate if the bioavailability could be increased by co-administration of the absorption enhancer Tween 20. Methods: The study was a non-blinded randomised balanced three-way crossover study in eight healthy male subjects. The subjects received 25mg i.v. M6G, 200mg oral M6G, and 50mg oral M6G+500mg of Tween 20. Blood samples were collected until 12h after i.v. administration and until 24h after oral administration. Paracetamol and sulfasalzine were co-administered with oral administrated M6G as markers for when the gut contents reached the duodenum and colon, respectively. Results: The pharmacokinetic profile of i.v. M6G was in close agreement with previously reported data (t"1"/"2 0.93+/-0.2h, CL 157+/-8ml/min, V"d","s"s 13.2+/-3.5l, and AUC"0"-"~ 5341+/-289nmol/l/h). After oral administration, neither bioavailability nor time to the first or second peak changed in the presence or absence of Tween 20 (F: 9.3+/-2.4 and 10.1+/-4.8%; t"1: 2.5 [1.0-6.1] and 5.0 [2.0-8.2]h; and t"2: 18.0 [11.0-20.0] and 20.0 [11.0-24.0]h, respectively). Conclusion: In this study, the pharmacokinetic profile of M6G was found to be in agreement with profiles found by others. Two different plasma concentration peaks were found after oral administration of M6G, the second of which occurred after the gut contents reached colon. Co-administration of Tween 20 did not enhance the bioavailability.

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